Lhb Gene Summary [Mouse]
Predicted to enable hormone activity. Acts upstream of or within luteinizing hormone signaling pathway involved in ovarian follicle development. Located in cytoplasm. Is expressed in alimentary system; brain; genitourinary system; and heart. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 23 with or without anosmia. Orthologous to several human genes including LHB (luteinizing hormone subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lhb |
| Official Name | luteinizing hormone beta [Source:MGI Symbol;Acc:MGI:96782] |
| Ensembl ID | ENSMUSG00000100916 |
| Bio databases IDs | |
| Aliases | luteinizing hormone beta |
| Synonyms | AC151602.1, CGB4, Gm29035, Gm683, HH23, LH, LH beta, LH β, LOC100040019, LOC100045896, LSH-B, LSH-beta, LSH-β, luteinizing hormone beta, luteinizing hormone subunit beta, luteinizing hormone subunit β, luteinizing hormone β, LUTROPIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lhb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- signal peptide
- hormone
- protein binding
- receptor binding
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Lhb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypoplasia
- endometriosis
- azoospermia
- polycystic ovary syndrome
- isolated lutropin deficiency
- luteal insufficiency
- anovulation
- premature ovarian failure
- obesity
role in cell
- development
- expression in
- apoptosis
- maturation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- perinuclear region
- Plasma Membrane
- cytoplasmic aggregates
- cytoplasmic vesicles
- secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lhb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- progesterone biosynthetic process
- male gonad development
- G-protein coupled receptor signaling pathway
- signal transduction
- cell-cell signaling
- hormone-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- Golgi lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding
- hormone activity