Arsk Gene Summary [Mouse]
Enables glucuronate-2-sulfatase activity. Predicted to be located in extracellular region and lysosome. Is expressed in aorta; genitourinary system; heart; and spinal cord. Used to study mucopolysaccharidosis. Human ortholog(s) of this gene implicated in mucopolysaccharidosis. Orthologous to human ARSK (arylsulfatase family member K). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arsk |
| Official Name | arylsulfatase K [Source:MGI Symbol;Acc:MGI:1924291] |
| Ensembl ID | ENSMUSG00000021592 |
| Bio databases IDs | |
| Aliases | arylsulfatase K |
| Synonyms | 2810429K17Rik, 4833414G15Rik, arylsulfatase family member K, arylsulfatase family, member K, arylsulfatase K, ASK, MPS10, RGD1310182, TSULF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arsk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- Sulfatase
- enzyme
- glucuronate-2-sulfatase
- arylsulfatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- lysosome
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arsk gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular region
- lysosome
Molecular Function
What the gene product does at the molecular level
- glucuronate-2-sulfatase activity
- metal ion binding
- arylsulfatase activity