Il5ra Gene Summary [Mouse]
Predicted to enable cytokine binding activity and interleukin-5 receptor activity. Acts upstream of or within inflammatory response to antigenic stimulus and regulation of interleukin-5 production. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in early conceptus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5RA (interleukin 5 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il5ra |
| Official Name | interleukin 5 receptor, alpha [Source:MGI Symbol;Acc:MGI:96558] |
| Ensembl ID | ENSMUSG00000005364 |
| Bio databases IDs | |
| Aliases | interleukin 5 receptor, alpha |
| Synonyms | CD125, CDw125, HSIL5R3, IL5R, IL-5R alpha, IL-5R α, interleukin 5 receptor, alpha, interleukin 5 receptor subunit alpha, interleukin 5 receptor subunit α, interleukin 5 receptor, α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il5ra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- interleukin-5 receptor
- cytoplasmic domain
- FN3
- ectodomain
- protein binding
- cytosolic tail domain
- cytokine receptor
- proline rich domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il5ra gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck neoplasia
- Alzheimer disease
- asthma
- eosinophilic esophagitis
- uncontrolled asthma
- severe pulmonary eosinophilia
- chronic idiopathic urticaria
- nasal polyp
- severe asthma
- chronic eosinophilic rhinosinusitis
role in cell
- proliferation
- apoptosis
- activation
- differentiation
- number
- abnormal morphology
- response
- abnormal number
- response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il5ra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response to antigenic stimulus
- interleukin-5-mediated signaling pathway
- signal transduction
- cytokine-mediated signaling pathway
- positive regulation of leukocyte proliferation
- regulation of interleukin-5 production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- external side of plasma membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-5 receptor activity
- cytokine receptor activity
- cytokine binding