Lipg Gene Summary [Mouse]
Enables phospholipase activity. Acts upstream of or within regulation of lipoprotein metabolic process. Predicted to be located in Golgi apparatus; cell surface; and early endosome. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in cardiovascular system disease; cerebral infarction; coronary artery disease; and myocardial infarction. Orthologous to human LIPG (lipase G, endothelial type). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lipg |
| Official Name | lipase, endothelial [Source:MGI Symbol;Acc:MGI:1341803] |
| Ensembl ID | ENSMUSG00000053846 |
| Bio databases IDs | |
| Aliases | lipase, endothelial |
| Synonyms | 3110013K01Rik, EDL, EL, lipase, lipase, endothelial, lipase G, endothelial type, mEDL, mEL, PRO719 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lipg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipase A1
- alpha/beta hydrolases
- lipase
- PLAT
- enzyme
- lipoprotein lipase
- Lipoxygenase homology 2 (beta barrel) domain
- glycosylation site
- phospholipase
- triacylglycerol lipase
Pathways
Biological processes and signaling networks where the Lipg gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- Alzheimer disease
- myocardial infarction
- metabolic syndrome X
- atherosclerosis
- HER2 negative hormone receptor negative breast cancer
- coronary artery disease
- testicular carcinoma
role in cell
- growth
- expression in
- quantity
- adhesion
- binding
- function
- oxidative phosphorylation in
- inhibition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Golgi Apparatus
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lipg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- high-density lipoprotein particle remodeling
- phospholipid catabolic process
- response to nutrient
- fatty acid biosynthetic process
- cholesterol homeostasis
- phospholipid homeostasis
- reverse cholesterol transport
- lipid metabolic process
- regulation of lipoprotein metabolic process
- positive regulation of cholesterol transport
- triglyceride catabolic process
- positive regulation of high-density lipoprotein particle clearance
Cellular Component
Where in the cell the gene product is active
- early endosome
- extracellular space
- Golgi apparatus
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- 1-acyl-2-lysophosphatidylserine acylhydrolase activity
- phosphatidylserine 1-acylhydrolase activity
- triglyceride lipase activity
- heparin binding
- phosphatidylcholine 1-acylhydrolase activity
- lipoprotein lipase activity
- phospholipase activity