Ly86 Gene Summary [Mouse]
Acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in extracellular region. Is expressed in cerebral cortex; genitourinary system; and lower leg bone. Orthologous to human LY86 (lymphocyte antigen 86). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ly86 |
| Official Name | lymphocyte antigen 86 [Source:MGI Symbol;Acc:MGI:1321404] |
| Ensembl ID | ENSMUSG00000021423 |
| Bio databases IDs | |
| Aliases | lymphocyte antigen 86 |
| Synonyms | dJ80N2.1, ly86 tv2, lymphocyte antigen 86, MD-1, MMD-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ly86 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ML
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- tinnitus
- lepromatous leprosy
- endometrial carcinoma
- epithelial endometrial cancer
- systemic sclerosis
- non-insulin-dependent diabetes mellitus
- venous thromboembolism
- insulin-dependent diabetes mellitus
- dextran sodium sulfate-induced colitis
role in cell
- expression in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ly86 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- innate immune response
- lipopolysaccharide-mediated signaling pathway
- positive regulation of lipopolysaccharide-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding