Slf1 Gene Summary [Mouse]
Enables ubiquitin protein ligase binding activity. Involved in DNA damage response. Located in centrosome; cytoplasm; and nuclear inclusion body. Part of nucleosome. Is expressed in cerebral cortex marginal layer; cerebral cortex subventricular zone; cerebral cortex ventricular layer; cortical plate; and medulla oblongata basal plate mantle layer. Orthologous to human SLF1 (SMC5-SMC6 complex localization factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slf1 |
| Official Name | SMC5-SMC6 complex localization factor 1 [Source:MGI Symbol;Acc:MGI:2145448] |
| Ensembl ID | ENSMUSG00000021597 |
| Bio databases IDs | |
| Aliases | SMC5-SMC6 complex localization factor 1 |
| Synonyms | 2700017A04RIK, ANKRD32, BRCTD1, BRCTX, C730024G01Rik, DKFZP761C121, LOC101929687, SMC5-SMC6 complex localization factor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- BRCT
- transcription regulator
- Ankyrin repeats (many copies)
- binding protein
- Regulator of Ty1 transposition protein 107 BRCT domain
- Ankyrin repeats (3 copies)
- protein binding
- breast cancer carboxy-terminal domain
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- nucleosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of maintenance of mitotic sister chromatid cohesion
- protein sumoylation
- double-strand break repair via homologous recombination
- response to DNA damage stimulus
- positive regulation of double-strand break repair
- positive regulation of protein complex assembly
- regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear inclusion body
- chromosome, telomeric region
- centrosome
- site of double-strand break
- cytoplasm
- Smc5-Smc6 complex
- nucleosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding