Ube2b Gene Summary [Mouse]
Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including chromosome organization; regulation of primary metabolic process; and sperm axoneme assembly. Located in XY body and chromatin. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human UBE2B (ubiquitin conjugating enzyme E2 B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2b |
| Official Name | ubiquitin-conjugating enzyme E2B [Source:MGI Symbol;Acc:MGI:102944] |
| Ensembl ID | ENSMUSG00000020390 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2B |
| Synonyms | 17-kDa Ubiquitin-Conjugating Enzyme E2, 2610301N02RIK, E2 14K, E2-17kDa, E2b, HHR6B, HR6B, LOC103694902, LOC81816, mHR6B, RAD6B, UBC2, ubiquitin-conjugating enzyme E2B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube2b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- uterine leiomyoma
- leiomyomatosis
- teratozoospermia
- systemic lupus erythematosus
- congenital heart disease
- oligozoospermia
- asthenozoospermia
- adenomyosis
- infection by HIV-1
role in cell
- apoptosis
- cell death
- growth
- quantity
- abnormal morphology
- organization
- arrangement
- formation
- fusion
- cisplatin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- nucleoplasm
- sex chromatin
- chromatin
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- response to UV
- negative regulation of developmental process
- response to xenobiotic stimulus
- chromatin organization
- postreplication repair
- chiasma assembly
- in utero embryonic development
- apoptotic process
- protein autoubiquitination
- protein K11-linked ubiquitination
- germ cell programmed cell death
- protein K48-linked ubiquitination
- protein polyubiquitination
- spermatogenesis
- positive regulation of canonical Wnt receptor signaling pathway
- sperm axoneme assembly
- response to DNA damage stimulus
- negative regulation of cAMP-mediated signaling
- ubiquitin-dependent protein catabolic process
- meiotic telomere clustering
- synaptonemal complex organization
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of reciprocal meiotic recombination
- negative regulation of apoptotic process
- protein K63-linked ubiquitination
- negative regulation of reproductive process
- protein stabilization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- replication fork
- XY body
- nucleus
- cytoplasm
- chromatin
- HULC complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- ATP binding
- ubiquitin protein ligase binding
- protein binding