Msln Gene Summary [Mouse]
Predicted to be involved in cell-matrix adhesion. Located in extracellular space. Is expressed in several structures, including body cavity or lining; genitourinary system; gut; heart; and respiratory system. Human ortholog(s) of this gene implicated in ovarian cancer; pancreas disease; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human MSLN (mesothelin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Msln |
| Official Name | mesothelin [Source:MGI Symbol;Acc:MGI:1888992] |
| Ensembl ID | ENSMUSG00000063011 |
| Bio databases IDs | |
| Aliases | mesothelin |
| Synonyms | mesothelin, MPF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Msln often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- fibrosis
- pancreatic adenocarcinoma
- ovarian cancer
- soft tissue sarcoma cancer
- mesothelioma formation
- pulmonary fibrosis
- mesothelial neoplasm
- serous ovarian adenocarcinoma
role in cell
- proliferation
- cell viability
- expression in
- activation in
- colony formation by
- cell cycle progression
- S phase
- stimulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- Extracellular Space
- cellular membrane
- Golgi Apparatus
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Msln gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- membrane
- Golgi apparatus
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding