Scamp1 Gene Summary [Mouse]
Predicted to enable protein domain specific binding activity. Acts upstream of or within establishment of localization in cell and exocytosis. Located in synaptic vesicle membrane and zymogen granule membrane. Is expressed in neural retinal epithelium; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human SCAMP1 (secretory carrier membrane protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scamp1 |
| Official Name | secretory carrier membrane protein 1 [Source:MGI Symbol;Acc:MGI:1349480] |
| Ensembl ID | ENSMUSG00000021687 |
| Bio databases IDs | |
| Aliases | secretory carrier membrane protein 1 |
| Synonyms | 4930505M11Rik, AI415563, SCAMP, SCAMP1 isoform 2, SCAMP37, secretory carrier membrane protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scamp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SCAMP family
- NPF motif
- protein domain specific binding
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- squamous cell cancer
- major depression
- thrombocytopenia
- idiopathic scoliosis
- squamous-cell carcinoma
regulates
- TF
- Tax
role in cell
- transport
- function
- exocytosis by
- closure
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- synaptic vesicle membrane
- cytoplasmic vesicle membrane
- membrane surface
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- specific granule membrane
- Golgi membrane
- trans Golgi network
- endosomal membrane
- zymogen granules
- synaptic vesicles
- synapse
- recycling endosomes
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scamp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- post-Golgi vesicle-mediated transport
- establishment of localization in cell
- endocytosis
- exocytosis
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- membrane
- synaptic vesicle membrane
- recycling endosome membrane
- clathrin-coated vesicle
- trans-Golgi network membrane
- zymogen granule membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding