Cenpk Gene Summary [Mouse]
Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system and neural retina. Orthologous to human CENPK (centromere protein K). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Cenpk |
| Official Name | centromere protein K [Source:MGI Symbol;Acc:MGI:1926210] |
| Ensembl ID | ENSMUSG00000021714 |
| Bio databases IDs | |
| Aliases | centromere protein K |
| Synonyms | AF5alpha, B130045K24Rik, C530004N04Rik, centromere protein K, FKSG14, P33, Solt, Solzt |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cenpk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Centromere-associated protein K
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphomagenesis
- renal clear cell adenocarcinoma
- incisional hernia
- androgenic alopecia
- small cell lung cancer
- diverticular disease
- renal clear cell cancer
- MYC mutation positive B-cell lymphoma
- B cell cancer
- nonsyndromic cleft lip and palate
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cenpk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic sister chromatid segregation
- chromosome segregation
- kinetochore assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed chromosome inner kinetochore
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding