Nop2 Gene Summary [Mouse]
Predicted to enable rRNA (cytosine-C5-)-methyltransferase activity. Acts upstream of or within blastocyst formation. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and tooth. Orthologous to human NOP2 (NOP2 nucleolar protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nop2 |
| Official Name | NOP2 nucleolar protein [Source:MGI Symbol;Acc:MGI:107891] |
| Ensembl ID | ENSMUSG00000038279 |
| Bio databases IDs | |
| Aliases | NOP2 nucleolar protein |
| Synonyms | A530002O17, NOL1, NOP120, NOP2 nucleolar protein, NSUN1, p120 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nop2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- rRNA (cytosine-C5-967)-methyltransferase
- NOL1/NOP2/sun family putative RNA methylase
- N-terminal domain of 16S rRNA methyltransferase RsmF
- 16S rRNA methyltransferase RsmB/F
- enzyme
- protein binding
- AdoMet_MTases
- P120R (NUC006) repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
role in cell
- proliferation
- expression in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nop2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of LSU-rRNA
- rRNA base methylation
- ribosomal large subunit biogenesis
- positive regulation of cell proliferation
- rRNA processing
- ribosomal large subunit assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- rRNA (cytosine-C5-)-methyltransferase activity
- RNA binding
- protein binding