Cenph Gene Summary [Mouse]
Enables kinetochore binding activity. Predicted to be involved in chromosome segregation and mitotic spindle organization. Predicted to act upstream of or within mitotic cell cycle. Located in kinetochore and nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and skin. Orthologous to human CENPH (centromere protein H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cenph |
| Official Name | centromere protein H [Source:MGI Symbol;Acc:MGI:1349448] |
| Ensembl ID | ENSMUSG00000045273 |
| Bio databases IDs | |
| Aliases | centromere protein H |
| Synonyms | 1700021I11Rik, 2410018A12Rik, 2610042E16Rik, 2810046K12Rik, centromere protein H, ENP, LOC681185 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cenph often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Centromere protein H (CENP-H)
- binding protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- MYC mutation positive B-cell lymphoma
- lymphomagenesis
- B cell cancer
role in cell
- aneuploidy
- organization
- segregation
- missegregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pericentrosomal region
- cytosol
- chromosome
- sister chromatids
- nucleoplasm
- nucleoli
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cenph gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic spindle organization
- kinetochore organization
- chromosome segregation
- kinetochore assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed chromosome inner kinetochore
- cytosol
- chromosome
- kinetochore
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- kinetochore binding
- protein binding