Rnf180 Gene Summary [Mouse]
Enables ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Acts upstream of or within several processes, including norepinephrine metabolic process; positive regulation of protein metabolic process; and serotonin metabolic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal medulla; central nervous system; genitourinary system; lens; and thymus. Orthologous to human RNF180 (ring finger protein 180). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf180 |
| Official Name | ring finger protein 180 [Source:MGI Symbol;Acc:MGI:1919066] |
| Ensembl ID | ENSMUSG00000021720 |
| Bio databases IDs | |
| Aliases | ring finger protein 180 |
| Synonyms | 3110001E11Rik, LOC683640, RINES, ring finger protein 180 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf180 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- E3 ubiquitin-protein ligase RNF180 C-terminus
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme binding
- enzyme
- Ring finger domain
- protein binding
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf180 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- norepinephrine metabolic process
- serotonin metabolic process
- protein polyubiquitination
- positive regulation of protein ubiquitination
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- adult behavior
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
Molecular Function
What the gene product does at the molecular level
- ubiquitin conjugating enzyme binding
- protein binding
- metal ion binding