Pcdh10 Gene Summary [Mouse]
Acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in central nervous system; dorsal root ganglion; genitourinary system; jaw bone; and rib. Orthologous to human PCDH10 (protocadherin 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcdh10 |
| Official Name | protocadherin 10 [Source:MGI Symbol;Acc:MGI:1338042] |
| Ensembl ID | ENSMUSG00000049100 |
| Bio databases IDs | |
| Aliases | protocadherin 10 |
| Synonyms | 6430521D13RIK, 6430703F07Rik, mKIAA1400, OL-pc, OL-PCDH, PCDH19, protocadherin 10, RGD1565811 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcdh10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nap1-binding site
- cytoplasmic domain
- Cadherin-like
- Cadherin repeat-like domain
- Cadherin cytoplasmic C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- metastasis
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- advanced cancer
- gait disturbance
- hyperactive behavior
role in cell
- expression in
- apoptosis
- growth
- colony formation by
- elimination
- elimination in
- migration
- development
- adhesion
- progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- actin filaments
- cell-cell contacts
- postsynaptic membrane
- synaptic vesicles
- synapse
- extracellular matrix
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcdh10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- cell adhesion
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding