Agrn

Enables several functions, including chondroitin sulfate binding activity; heparan sulfate proteoglycan binding activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of sodium ion transmembrane transport; positive regulation of Rac protein signal transduction; and positive regulation of protein modification process. Acts upstream of or within several processes, including Rac protein signal transduction; positive regulation of motor neuron apoptotic process; and protein localization to membrane. Located in basement membrane; cell surface; and sarcolemma. Is active in extracellular space and synapse. Is expressed in several structures, including epithelium; lower jaw; musculature; nervous system; and retina. Used to study congenital myasthenic syndrome 8. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Agrn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Agrn gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Agrn gene, providing context for its role in the cell.