Nid2 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within cell-matrix adhesion. Located in basement membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; musculature; and nervous system. Orthologous to human NID2 (nidogen 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nid2 |
| Official Name | nidogen 2 [Source:MGI Symbol;Acc:MGI:1298229] |
| Ensembl ID | ENSMUSG00000021806 |
| Bio databases IDs | |
| Aliases | nidogen 2 |
| Synonyms | entactin-2, Ly111, nidogen-2, OSTEONIDOGEN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nid2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nidogen-like
- Complement Clr-like EGF-like
- TY
- Human growth factor-like EGF
- extracellular matrix structural constituent
- collagen binding
- EGF domain
- nidG2
- protein binding
- Low-density lipoprotein receptor repeat class B
- Low-density lipoprotein-receptor YWTD domain
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- hearing loss
- tinnitus
- androgenic alopecia
- Goldenhar syndrome
- sensorineural hearing loss
- Hutchinson-Gilford progeria syndrome
- age-related hearing loss
- lung metastasis
- colonic polyp
role in cell
- morphology
- differentiation
- adhesion
- replicative senescence
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Plasma Membrane
- extracellular matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nid2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- basement membrane organization
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular space
- extracellular vesicular exosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- collagen binding
- calcium ion binding
- extracellular matrix structural constituent