Susd4 Gene Summary [Mouse]
Involved in regulation of postsynaptic neurotransmitter receptor internalization. Is active in parallel fiber to Purkinje cell synapse and postsynaptic membrane. Is expressed in brain and cortical plate. Orthologous to human SUSD4 (sushi domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Susd4 |
| Official Name | sushi domain containing 4 [Source:MGI Symbol;Acc:MGI:2138351] |
| Ensembl ID | ENSMUSG00000038576 |
| Bio databases IDs | |
| Aliases | sushi domain containing 4 |
| Synonyms | E430021N18Rik, FLJ10052, PRO222, RGD1564043, sushi domain containing 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Susd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- protein binding
- Sushi repeat (SCR repeat)
- SUSHI repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- extracellular granule
- postsynaptic membrane
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Susd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of complement activation, classical pathway
- negative regulation of complement activation, alternative pathway
- regulation of complement activation
- complement activation, classical pathway
- innate immune response
Cellular Component
Where in the cell the gene product is active
- membrane
- extracellular region