Hacl1 Gene Summary [Mouse]
Enables carbon-carbon lyase activity. Involved in fatty acid alpha-oxidation. Acts upstream of or within lipid metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in peroxisome. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Hacl1 |
| Official Name | 2-hydroxyacyl-CoA lyase 1 [Source:MGI Symbol;Acc:MGI:1929657] |
| Ensembl ID | ENSMUSG00000021884 |
| Bio databases IDs | |
| Aliases | 2-hydroxyacyl-CoA lyase 1 |
| Synonyms | 1600020H07Rik, 2-HPCL, 2-hydroxyacyl-CoA lyase 1, 2-Hydroxyphytanoyl-Coa Lyase, HPCL, HPCL2, PHYH2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hacl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
- carbon-carbon lyase
- vitamin binding
- TPP_enzymes
- aldehyde lyase
- sulfoacetaldehyde acetyltransferase
- oxalyl-CoA decarboxylase
- ATP binding
- acetolactate synthase, large subunit, biosynthetic type
- enzyme
- protein binding
- magnesium ion binding
- identical protein binding
- Thiamine pyrophosphate enzyme, central domain
- binding protein
- lyase
- thiamine pyrophosphate-dependent enzyme pyrimidine binding domain
- Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
- acetolactate synthase large subunit
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- androgenic alopecia
- diabetic nephropathy
regulates
- pristanal
- 2-hydroxyphytanoyl-coenzyme A
- fatty acid
- lipid
- phytanic acid
- 2-hydroxyoctadecanoyl-coenzyme A
- heptadecanal
role in cell
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- intracellular membrane-bounded organelle
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hacl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- methyl-branched fatty acid metabolic process
- protein targeting to peroxisome
- fatty acid alpha-oxidation
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- intracellular membrane-bounded organelle
- cytosol
- peroxisomal matrix
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- thiamine pyrophosphate binding
- ATP binding
- identical protein binding
- protein binding
- carbon-carbon lyase activity