Elovl3 Gene Summary [Mouse]
Predicted to enable fatty acid elongase activity. Involved in fatty acid biosynthetic process and positive regulation of cold-induced thermogenesis. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in brown fat; embryo; head; and skin. Orthologous to human ELOVL3 (ELOVL fatty acid elongase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Elovl3 |
| Official Name | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 [Source:MGI Symbol;Acc:MGI:1195976] |
| Ensembl ID | ENSMUSG00000038754 |
| Bio databases IDs | |
| Aliases | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 |
| Synonyms | CIG-30, CIN-2, Elovl3 (predicted), ELOVL fatty acid elongase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Elovl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GNS1/SUR4 family
- fatty acid elongase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- skin barrier defect
- psoriasis
- hypotrichosis
- senile lentigo
- hyperplasia
- dermatitis
role in cell
- abnormal morphology
- accumulation
- adipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Elovl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- unsaturated fatty acid biosynthetic process
- long-chain fatty-acyl-CoA biosynthetic process
- linoleic acid metabolic process
- alpha-linolenic acid metabolic process
- very long-chain fatty acid biosynthetic process
- fatty acid elongation, saturated fatty acid
- fatty acid elongation, polyunsaturated fatty acid
- fatty acid elongation, monounsaturated fatty acid
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- fatty acid elongase activity