Mettl6 Gene Summary [Mouse]
Enables tRNA (cytidine-3-)-methyltransferase activity. Involved in tRNA methylation. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human METTL6 (methyltransferase 6, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mettl6 |
| Official Name | methyltransferase like 6 [Source:MGI Symbol;Acc:MGI:1914261] |
| Ensembl ID | ENSMUSG00000021891 |
| Bio databases IDs | |
| Aliases | methyltransferase like 6 |
| Synonyms | 1600013P15Rik, hMETTL6, methyltransferase 6, methylcytidine, methyltransferase 6, tRNA N3-cytidine |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mettl6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme binding
- enzyme
- protein binding
- tRNA (cytosine)-methyltransferase
- AdoMet_MTases
- methyltransferase domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mettl6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA methylation
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- tRNA (cytosine-3-)-methyltransferase activity
- enzyme binding