Pdlim5 Gene Summary [Mouse]
Predicted to enable actin binding activity; muscle alpha-actinin binding activity; and protein kinase C binding activity. Predicted to be involved in actin cytoskeleton organization; cell growth involved in cardiac muscle cell development; and regulation of synapse organization. Located in Z disc. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb mesenchyme; and musculoskeletal system. Used to study dilated cardiomyopathy. Orthologous to human PDLIM5 (PDZ and LIM domain 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdlim5 |
| Official Name | PDZ and LIM domain 5 [Source:MGI Symbol;Acc:MGI:1927489] |
| Ensembl ID | ENSMUSG00000028273 |
| Bio databases IDs | |
| Aliases | PDZ and LIM domain 5 |
| Synonyms | 1110001A05Rik, ENH, ENH1, Enh2, Enh3, L9, LIM, PDLI5, PDZ and LIM domain 5, PDZ-LIM5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdlim5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4749)
- Domain present in PSD-95, Dlg, and ZO-1/2
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- actin binding
- actinin binding
- protein kinase C binding
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- myocardial infarction
- Alzheimer disease
- endometriosis
- prostate cancer
- major depression
- epithelial cancer
- cancer
- breast cancer
- prostatic carcinoma
role in cell
- expression in
- number
- abnormal morphology
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- cellular membrane
- actin cytoskeleton
- cytosol
- Z line
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdlim5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendritic spine morphogenesis
- heart development
- muscle structure development
- cell growth involved in cardiac muscle cell development
- actin cytoskeleton organization
- regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- Z disc
- postsynaptic density
- adherens junction
- stress fiber
- membrane
- actin cytoskeleton
- cytosol
- filamentous actin
- cell projection
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- protein binding
- actin binding
- metal ion binding
- actinin binding
- muscle alpha-actinin binding