Stim1

Enables channel regulator activity and identical protein binding activity. Involved in ligand-gated ion channel signaling pathway; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within establishment of localization in cell; myotube differentiation; and store-operated calcium entry. Located in endoplasmic reticulum. Is active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; gonad; hemolymphoid system gland; and musculature. Used to study Stormorken syndrome and tubular aggregate myopathy 1. Human ortholog(s) of this gene implicated in Stormorken syndrome; gastrointestinal system cancer (multiple); immunodeficiency 10; lung cancer; and tubular aggregate myopathy 1. Orthologous to human STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stim1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Stim1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Stim1 gene, providing context for its role in the cell.