Sfr1 Gene Summary [Mouse]
Predicted to enable transcription coactivator activity. Involved in double-strand break repair via homologous recombination. Located in nucleus. Part of Swi5-Sfr1 complex. Is expressed in olfactory cortex ventricular layer; pancreas epithelium; and telencephalon ventricular layer. Orthologous to human SFR1 (SWI5 dependent homologous recombination repair protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sfr1 |
| Official Name | SWI5 dependent recombination repair 1 [Source:MGI Symbol;Acc:MGI:1915038] |
| Ensembl ID | ENSMUSG00000025066 |
| Bio databases IDs | |
| Aliases | SWI5 dependent recombination repair 1 |
| Synonyms | 6330577E15Rik, bA373N18.1, C10orf78, LRRGT00030, MEI5, MEIR5, RGD1305481, SWI5-dependent homologous recombination repair protein 1, SWI5 dependent recombination repair 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sfr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- Double-strand recombination repair protein
- coiled-coil domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sfr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- double-strand break repair via homologous recombination
- cellular response to estrogen stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- nucleolus
- nucleoplasm
- Swi5-Sfr1 complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- ligand-dependent nuclear receptor transcription coactivator activity