Nufip1 Gene Summary [Mouse]
Enables RNA binding activity. Predicted to be involved in box C/D snoRNP assembly and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is active in synapse. Is expressed in early conceptus; inner cell mass; oocyte; and trophectoderm. Orthologous to human NUFIP1 (nuclear FMR1 interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nufip1 |
| Official Name | nuclear fragile X mental retardation protein interacting protein 1 [Source:MGI Symbol;Acc:MGI:1351474] |
| Ensembl ID | ENSMUSG00000022009 |
| Bio databases IDs | |
| Aliases | nuclear fragile X mental retardation protein interacting protein 1 |
| Synonyms | bA540M5.1, nuclear FMR1 interacting protein 1, NUFIP, Rsa1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nufip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- Zinc-finger double-stranded RNA-binding
- pep motif
- protein binding activity, bridging
- Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
- snoRNA binding
- protein binding
- zinc finger domain
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- polyribosome fractions
- fibrillar center
- nuclear chromatin
- nuclear foci
- nucleoplasm
- nucleoli
- nuclear matrix
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nufip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- box C/D snoRNP assembly
- RNA processing
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription elongation factor complex
- presynaptic active zone
- perichromatin fibrils
- pre-snoRNP complex
- nuclear matrix
- macromolecular complex
- nucleolus
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- snoRNA binding
- RNA binding
- protein binding
- metal ion binding
- protein binding, bridging
- ATPase binding