Amph Gene Summary [Mouse]
Predicted to enable phosphatase binding activity and phospholipid binding activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within learning. Located in synaptic vesicle. Is active in glutamatergic synapse; photoreceptor ribbon synapse; and presynaptic endocytic zone. Is expressed in several structures, including allantois; brain; genitourinary system; liver; and septum transversum. Orthologous to human AMPH (amphiphysin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Amph |
| Official Name | amphiphysin [Source:MGI Symbol;Acc:MGI:103574] |
| Ensembl ID | ENSMUSG00000021314 |
| Bio databases IDs | |
| Aliases | amphiphysin |
| Synonyms | AMPH1, Amph i, amphiphysin, Amphiphysin1, Amphiphysin I, LOC100909679, LOC103690678, LOC687233 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Amph often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- clathrin binding domain
- binding protein
- BAR domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- proline rich domain
- Src Homology 3 domain superfamily
- phosphatase binding
- DPF domain
Pathways
Biological processes and signaling networks where the Amph gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- schizophrenia
- liver cancer
- epithelial cancer
- Alzheimer disease
- ductal breast carcinoma
- ductal breast cancer
- seizures
- small vessel disease stroke
- Waldenström macroglobulinemia
role in cell
- exocytosis
- fusion
- release
- replication in
- abnormal morphology
- endocytosis
- endocytosis by
- recycling
- cleavage in
- tie off in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- cellular membrane
- actin cytoskeleton
- actin filaments
- cytosol
- synaptic vesicles
- growth cone
- nerve ending
- synaptosomes
- ruffled borders
- cell membrane leading edge
- axon terminals
- presynaptic terminals
- ribbon synapse
- clathrin-coated vesicles
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Amph gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic vesicle endocytosis
- synaptic transmission
- endocytosis
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- actin cytoskeleton
- leading edge membrane
- cytosol
- synaptic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phospholipid binding