Trim35 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of myeloid cell apoptotic process. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; lung; and sensory organ. Orthologous to human TRIM35 (tripartite motif containing 35). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim35 |
| Official Name | tripartite motif-containing 35 [Source:MGI Symbol;Acc:MGI:1914104] |
| Ensembl ID | ENSMUSG00000022043 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 35 |
| Synonyms | 0710005M05Rik, A430106H13Rik, HLS5, MAIR, mKIAA1098, NC8, tripartite motif-containing 35 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim35 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- B-Box C-terminal domain
- SPRY domain
- zinc finger of C3HC4-type, RING
- Ring finger domain
- protein binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- Ring finger
- B-box zinc finger
- SPRY-associated domain
- Domain of unknown function (DUF4200)
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung carcinoma
- lung carcinoma process
- small cell lung carcinoma
- small cell lung cancer
- non-specific interstitial pneumonia
- mucopolysaccharidosis type IVB
- hepatocellular dysplasia
- metabolic syndrome X
- restless legs syndrome
regulates
role in cell
- apoptosis
- growth
- phosphorylation in
- proliferation
- clonogenicity
- tumorigenicity
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim35 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- apoptotic process
- positive regulation of apoptotic process
- negative regulation of mitotic cell cycle
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding