Osmr Gene Summary [Mouse]
Enables cytokine binding activity and oncostatin-M receptor activity. Predicted to be involved in oncostatin-M-mediated signaling pathway and positive regulation of cell population proliferation. Predicted to act upstream of or within cell surface receptor signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; choroid plexus; hemolymphoid system; lung; and skeletal system. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 1. Orthologous to human OSMR (oncostatin M receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Osmr |
| Official Name | oncostatin M receptor [Source:MGI Symbol;Acc:MGI:1330819] |
| Ensembl ID | ENSMUSG00000022146 |
| Bio databases IDs | |
| Aliases | oncostatin M receptor |
| Synonyms | c12, IL-31RB, IL-31R-beta, IL-31R-β, oncostatin M receptor, OSMRB, OSMR beta, OSMR β, PLCA1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Osmr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- STAT binding domain
- proline-rich box
- extracellular domain
- cytokine binding
- tyrosine activation motif
- protein binding
- phosphotyrosine binding domain
- Fibronectin type 3 domain
- Leukemia inhibitory factor receptor D2 domain
- YXXP domain
- cytoplasmic domain
- FN3
- oncostatin-M receptor
- transmembrane domain
- intracellular domain
- transmembrane receptor
- growth factor binding
Pathways
Biological processes and signaling networks where the Osmr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- angioimmunoblastic T-cell lymphoma
- epithelial cancer
- COVID-19
- insulin resistance
- inflammatory bowel disease
- ovarian cancer
- primary central nervous system lymphoma
- primary cancer
- lymphomagenesis
- central nervous system cancer
role in cell
- binding in
- migration
- proliferation
- expression in
- phosphorylation in
- growth
- accumulation
- apoptosis
- degeneration
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- plasma membrane extracellular face
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Osmr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of acute inflammatory response
- response to cytokine stimulus
- oncostatin-M-mediated signaling pathway
- cytokine-mediated signaling pathway
- positive regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- oncostatin-M receptor complex
- external side of plasma membrane
- receptor complex
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- growth factor binding
- protein binding
- oncostatin-M receptor activity
- ciliary neurotrophic factor receptor binding
- cytokine receptor activity
- cytokine binding