Dmtn Gene Summary [Mouse]
Predicted to enable actin filament binding activity; signaling receptor binding activity; and spectrin binding activity. Involved in several processes, including negative regulation of cell-substrate adhesion; negative regulation of protein phosphorylation; and negative regulation of protein targeting to membrane. Located in several cellular components, including cortical cytoskeleton; perinuclear region of cytoplasm; and postsynaptic density. Is active in synapse. Is expressed in central nervous system; dorsal root ganglion; liver lobe; and sensory organ. Orthologous to human DMTN (dematin actin binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dmtn |
| Official Name | dematin actin binding protein [Source:MGI Symbol;Acc:MGI:99670] |
| Ensembl ID | ENSMUSG00000022099 |
| Bio databases IDs | |
| Aliases | dematin actin binding protein |
| Synonyms | DEMATIN, dematin actin binding protein, DMT, EPB49, EPB4.9, Epb4.9 predicted, Erythrocyte Membrane Protein Band 4.9 (Dematin), protein 4.9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dmtn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RXXs motif
- PXsP motif
- actin binding
- spectrin binding
- Villin headpiece domain
- protein binding
- receptor binding
- headpiece domain
- Putative adherens-junction anchoring region of AbLIM
- Serine Proline motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal cell carcinoma
- renal cell cancer
- anemia
- spherocytosis
- osteoarthritis
- microcytosis
role in cell
- activation in
- expression in
- migration
- adhesion
- binding
- morphology
- secretion
- aggregation
- quantity
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cortical cytoskeleton
- cell center
- cytoskeleton
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- actin cytoskeleton
- Nucleus
- actin filaments
- cytosol
- perinuclear space
- synapse
- cytoplasmic vesicles
- junctional complexes
- cellular protrusions
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dmtn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein targeting to membrane
- regulation of cell shape
- positive regulation of blood coagulation
- cytoskeleton organization
- regulation of filopodium assembly
- smooth endoplasmic reticulum calcium ion homeostasis
- cellular response to calcium ion
- negative regulation of cell-substrate adhesion
- negative regulation of peptidyl-serine phosphorylation
- negative regulation of peptidyl-tyrosine phosphorylation
- regulation of lamellipodium assembly
- positive regulation of wound healing
- macromolecular complex assembly
- negative regulation of substrate adhesion-dependent cell spreading
- erythrocyte development
- negative regulation of focal adhesion assembly
- regulation of actin cytoskeleton organization
- actin filament capping
- negative regulation of peptidyl-threonine phosphorylation
- cellular response to cAMP
- lamellipodium assembly
- endoplasmic reticulum tubular network organization
- actin cytoskeleton organization
- positive regulation of fibroblast migration
- actin filament bundle assembly
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- smooth endoplasmic reticulum
- platelet dense tubular network membrane
- actin filament
- plasma membrane
- perinuclear region of cytoplasm
- actin cytoskeleton
- cytosol
- cytoplasmic vesicle
- cell projection membrane
- cortical cytoskeleton
- spectrin-associated cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- actin binding
- spectrin binding
- receptor binding