Rasgrf2 Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within long-term synaptic potentiation and regulation of NMDA receptor activity. Is active in glutamatergic synapse. Is expressed in brain; hypothalamus mantle layer; medulla oblongata basal plate mantle layer; and pons mantle layer. Orthologous to human RASGRF2 (Ras protein specific guanine nucleotide releasing factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rasgrf2 |
| Official Name | RAS protein-specific guanine nucleotide-releasing factor 2 [Source:MGI Symbol;Acc:MGI:109137] |
| Ensembl ID | ENSMUSG00000021708 |
| Bio databases IDs | |
| Aliases | RAS protein-specific guanine nucleotide-releasing factor 2 |
| Synonyms | 6330417G04RIK, GRF2, GRP2, RAS protein-specific guanine nucleotide-releasing factor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rasgrf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- IQ domain
- PH domain
- protein binding
- RasGEF
- Cdc25 domain
- Pleckstrin homology-like domain
- Dbl homology domain
- RhoGEF domain
Pathways
Biological processes and signaling networks where the Rasgrf2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- eating disorder
- pancreatic cancer
- refractive error
- neoplastic cell transformation
- ischemic injury
- insomnia
- colorectal mucinous adenocarcinoma
- colorectal carcinomagenesis
- ductal breast carcinoma
role in cell
- growth
- proliferation
- phosphorylation in
- morphology
- activation in
- function
- damage
- blast transformation
- cell-cell contact
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- perinuclear space
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rasgrf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- long-term synaptic potentiation
- Ras protein signal transduction
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytosol
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- guanyl-nucleotide exchange factor activity