Sdc2 Gene Summary [Mouse]
Predicted to enable PDZ domain binding activity and identical protein binding activity. Involved in regulation of dendrite morphogenesis. Predicted to be located in neuronal cell body and plasma membrane. Predicted to be active in cell surface. Is expressed in several structures, including cranium; embryo mesenchyme; genitourinary system; jaw; and retina. Human ortholog(s) of this gene implicated in cleft lip and cleft palate. Orthologous to human SDC2 (syndecan 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sdc2 |
| Official Name | syndecan 2 [Source:MGI Symbol;Acc:MGI:1349165] |
| Ensembl ID | ENSMUSG00000022261 |
| Bio databases IDs | |
| Aliases | syndecan 2 |
| Synonyms | 4833414L08RIK, CD362, heparan sulphate proteoglycan 1, HSPG, HSPG1, SYND2, syndecan-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sdc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- EFYA motif
- ectodomain
- protein binding
- identical protein binding
- PDZ-domain binding
- putative band 4.1 homologues' binding motif
- Syndecan domain
- cytoplasmic domain
- transmembrane domain
- glycosaminoglycan attachment site
- intracellular domain
- C2 region of the Syndecan family
Pathways
Biological processes and signaling networks where the Sdc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- refractive error
- rheumatoid arthritis
- neoplasia
- cutaneous melanoma
- cutaneous melanoma cancer
- systemic sclerosis
- psoriatic arthritis
- colon adenocarcinoma
- colon epithelial cancer
role in cell
- expression in
- deposition
- adhesion
- proliferation
- growth
- apoptosis
- activation in
- morphology
- signaling in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi lumen
- glutaminergic synapse
- Cytoplasm
- cell surface
- cellular membrane
- endoplasmic reticulum lumen
- presynaptic membrane
- postsynaptic membrane
- lysosomal compartment
- synaptosomes
- synapse
- basal lamina
- perikaryon
- dendrites
- axon terminals
- basement membrane
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sdc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell migration
- regulation of dendrite morphogenesis
- dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- lysosomal lumen
- Golgi lumen
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- PDZ domain binding