Ephb2 Gene Summary [Mouse]
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors consist of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. The encoded receptor preferentially binds membrane-bound ephrin-B ligands and is involved in nervous system and vascular development. This gene is used as a marker of intestinal stem cells. Homozygous knockout mice for this gene exhibit impaired axon guidance and vestibular function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Ephb2 |
| Official Name | Eph receptor B2 [Source:MGI Symbol;Acc:MGI:99611] |
| Ensembl ID | ENSMUSG00000028664 |
| Bio databases IDs | |
| Aliases | Eph receptor B2 |
| Synonyms | BDPLT22, CAPB, Cek5, DRT, EK5, EPH receptor B2, EPHT3, EPTH3, ERK, ETECK, Hek5, LOC103689967, NAF2, Nuk, PCBC, Prkm5, Qek5, RGD1564232, Sek3, Tyro5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ephb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP-binding domain
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- Sterile alpha motif
- transmembrane-ephrin receptor
- cytoplasmic domain
- SAM domain (Sterile alpha motif)
- intracellular domain
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- p120rasgap binding domain
- Ligand Binding Domain of Ephrin Receptors
- extracellular domain
- Protein kinase (unclassified specificity)
- signaling receptor activity
- Protein tyrosine and serine/threonine kinase
- axon guidance receptor
- SAM (Sterile alpha motif )
- ectodomain
- ephrin receptor
- protein binding
- receptor binding
- beta-amyloid binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
- FN3
- tyrosine phosphorylation site
- Ephrin receptor ligand binding domain
Pathways
Biological processes and signaling networks where the Ephb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- cleft palate
- Huntington disease
- epithelial cancer
- cutaneous melanoma
- prostate cancer/brain cancer susceptibility
- cutaneous melanoma cancer
- pancreatic cancer
- hyperactive behavior
- cleft palate syndrome
role in cell
- formation
- formation in
- expression in
- cell death
- apoptosis
- survival
- phosphorylation in
- replication in
- migration
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- Extracellular Space
- postsynaptic region
- cellular membrane
- cell-cell contacts
- cytosol
- presynaptic membrane
- postsynaptic membrane
- nucleoplasm
- dendritic spines
- growth cone
- neurites
- synaptosomes
- synapse
- membrane processes
- filopodia
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ephb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- regulation of blood coagulation
- central nervous system projection neuron axonogenesis
- axon guidance
- negative regulation of cytokine production involved in inflammatory response
- learning
- optic nerve morphogenesis
- learning or memory
- axonal fasciculation
- regulation of filopodium assembly
- regulation of T-helper 17 type immune response
- negative regulation of Ras protein signal transduction
- regulation of neuronal synaptic plasticity
- positive regulation of synaptic plasticity
- positive regulation of immunoglobulin production
- positive regulation of tumor necrosis factor production
- regulation of body fluid levels
- positive regulation of synapse assembly
- positive regulation of dendritic spine morphogenesis
- positive regulation of protein localization at cell surface
- regulation of JAK-STAT cascade
- dendritic spine development
- dendritic spine morphogenesis
- corpus callosum development
- positive regulation of gene expression
- inner ear morphogenesis
- ephrin receptor signaling pathway
- positive regulation of B cell proliferation
- positive regulation of cell migration
- positive regulation of long-term neuronal synaptic plasticity
- positive regulation of long-term synaptic potentiation
- hindbrain tangential cell migration
- palate development
- nervous system development
- B cell activation
- protein phosphorylation
- negative regulation of protein kinase activity
- negative regulation of axonogenesis
- postsynaptic membrane assembly
- angiogenesis
- phosphorylation
- commissural neuron axon guidance
- retinal ganglion cell axon guidance
- negative regulation of cell adhesion
- camera-type eye morphogenesis
- urogenital system development
- regulation of behavioral fear response
- cellular response to lipopolysaccharide
- negative regulation of protein phosphorylation
- negative regulation of ERK1 and ERK2 cascade
- regulation of autophagic vacuole assembly
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- dendrite
- postsynaptic membrane
- dendritic spine
- cytosol
- neuronal cell body
- extracellular region
- axon
- plasma membrane
- cell surface
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein tyrosine kinase activity
- protein binding
- axon guidance receptor activity
- receptor binding
- beta-amyloid binding
- transmembrane-ephrin receptor activity