Emc2 Gene Summary [Mouse]
Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in mitochondrion. Orthologous to human EMC2 (ER membrane protein complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Emc2 |
| Official Name | ER membrane protein complex subunit 2 [Source:MGI Symbol;Acc:MGI:1913986] |
| Ensembl ID | ENSMUSG00000022337 |
| Bio databases IDs | |
| Aliases | ER membrane protein complex subunit 2 |
| Synonyms | 4921531G14Rik, ER membrane protein complex subunit 2, KIAA0103, RGD1310430, TTC35 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Emc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bacterial transcriptional activator domain
- protein binding
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pH resistant lipid raft fraction
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- inner nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Emc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein insertion into ER membrane by stop-transfer membrane-anchor sequence
- tail-anchored membrane protein insertion into ER membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extrinsic to endoplasmic reticulum membrane
- cytoplasm
- ER membrane protein complex
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- membrane insertase activity
- protein binding