Ctr9 Gene Summary [Mouse]
Enables SH2 domain binding activity. Involved in several processes, including cell surface receptor signaling pathway; cellular response to lipopolysaccharide; and endodermal cell fate commitment. Acts upstream of or within blastocyst development and negative regulation of gene expression, epigenetic. Located in euchromatin and nucleus. Part of Cdc73/Paf1 complex. Is expressed in cerebral cortex and telencephalon. Orthologous to human CTR9 (CTR9 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctr9 |
| Official Name | CTR9 homolog, Paf1/RNA polymerase II complex component [Source:MGI Symbol;Acc:MGI:109345] |
| Ensembl ID | ENSMUSG00000005609 |
| Bio databases IDs | |
| Aliases | CTR9 homolog, Paf1/RNA polymerase II complex component |
| Synonyms | AA409336, CTR9 homolog, Paf1/RNA polymerase II complex component, KIAA0155, mKIAA0155, p150, p150TSP, SH2BP1, TSBP, Tsp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctr9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tol-pal system protein YbgF
- SH2-domain binding
- putative PEP-CTERM system TPR-repeat lipoprotein
- Serine-rich region of AP3B1, clathrin-adaptor complex
- protein binding
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ovarian carcinoma
- diabetic nephropathy
- hereditary disorder
- organismal death
- major depression
- epithelial ovarian cancer
- pervasive developmental disorder
- collagen-induced arthritis
- medulloblastoma
- brain cancer
role in cell
- expression in
- growth
- recruitment in
- binding in
- differentiation
- frequency
- GSK343 sensitivity
- organization
- proliferative capacity
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctr9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of myeloid cell differentiation
- negative regulation of gene expression, epigenetic
- stem cell maintenance
- positive regulation of transcription from RNA polymerase II promoter
- JAK-STAT cascade
- transcription elongation from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- endodermal cell fate commitment
- blastocyst growth
- cellular response to lipopolysaccharide
- blastocyst hatching
- inner cell mass cell differentiation
- Wnt receptor signaling pathway
- interleukin-6-mediated signaling pathway
- trophectodermal cell differentiation
Cellular Component
Where in the cell the gene product is active
- euchromatin
- nuclear speck
- Cdc73/Paf1 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH2 domain binding
- RNA polymerase II core binding