Tctn3 Gene Summary [Mouse]
Involved in cilium assembly. Predicted to be located in nucleus. Is expressed in several structures, including brain and olfactory epithelium. Human ortholog(s) of this gene implicated in Joubert syndrome 18 and orofaciodigital syndrome IV. Orthologous to human TCTN3 (tectonic family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tctn3 |
| Official Name | tectonic family member 3 [Source:MGI Symbol;Acc:MGI:1914840] |
| Ensembl ID | ENSMUSG00000025008 |
| Bio databases IDs | |
| Aliases | tectonic family member 3 |
| Synonyms | 4930521E07Rik, C10orf61, JBTS18, LOC100912537, OFD4, RGD1305166, TECT3, tectonic family member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tctn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tectonic domain DUF1619
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- Joubert syndrome type 18
- Joubert syndrome related disorder
- holoprosencephaly
- orofaciodigital syndrome type 4
- hereditary disorder
- ciliopathy
- diverticular disease
- polydactyly
role in cell
- apoptosis
- abnormal morphology
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ciliary transition zone
- cilia
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tctn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- positive regulation of apoptotic process
- apoptotic process
- smoothened signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cilium membrane
Molecular Function
What the gene product does at the molecular level
- protein binding