Brd1 Gene Summary [Mouse]
Enables histone reader activity. Involved in positive regulation of erythrocyte differentiation. Part of histone H3-K14 acetyltransferase complex. Is expressed in brain; genitourinary system; and olfactory epithelium. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human BRD1 (bromodomain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brd1 |
| Official Name | bromodomain containing 1 [Source:MGI Symbol;Acc:MGI:1924161] |
| Ensembl ID | ENSMUSG00000022387 |
| Bio databases IDs | |
| Aliases | bromodomain containing 1 |
| Synonyms | 1110059H06Rik, BRL, bromodomain containing 1, BRPF1, BRPF2, LOC380958, mKIAA4191 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- PHD zinc finger
- transcription regulator
- histone acetyltransferase
- Enhancer of polycomb-like
- protein binding activity, bridging
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
- Bromodomain
- PHD-finger
- PHD-like zinc-binding domain
- PHD finger superfamily
- PHD-zinc-finger like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- schizophrenia
- Alzheimer disease
- vascular dementia
- growth failure
regulated by
- histone H3
role in cell
- apoptosis
- expression in
- differentiation
- erythropoiesis
- missegregation
- number
- missegregation in
- dipeptide repeat protein sensitivity
- homologous recombination repair in
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nuclear speckles
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of developmental process
- chromatin remodeling
- regulation of transcription, DNA-dependent
- response to immobilization stress
- response to electrical stimulus
- positive regulation of erythrocyte differentiation
- regulation of transcription from RNA polymerase II promoter
- erythrocyte maturation
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- nuclear speck
- MOZ/MORF histone acetyltransferase complex
- perikaryon
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- histone binding
- histone acetyltransferase activity (H4-K8 specific)
- histone acetyltransferase activity (H4-K5 specific)
- histone acetyltransferase activity (H4-K12 specific)