Tarbp2 Gene Summary [Mouse]
Predicted to enable several functions, including RNA binding activity; protein homodimerization activity; and protein sequestering activity. Predicted to contribute to pre-miRNA binding activity. Acts upstream of or within several processes, including positive regulation of muscle cell differentiation; regulation of gene expression; and spermatid development. Part of RISC complex and RISC-loading complex. Is expressed in brain and early embryo. Orthologous to human TARBP2 (TARBP2 subunit of RISC loading complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Tarbp2 |
| Official Name | TARBP2, RISC loading complex RNA binding subunit [Source:MGI Symbol;Acc:MGI:103027] |
| Ensembl ID | ENSMUSG00000023051 |
| Bio databases IDs | |
| Aliases | TARBP2, RISC loading complex RNA binding subunit |
| Synonyms | LOQS, Prbp, TARBP2, RISC loading complex RNA binding subunit, TARBP2 subunit of RISC loading complex, TRBP, TRBP1, TRBP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tarbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Double-stranded RNA binding motif
- double-stranded RNA binding motif (DSRM) superfamily
- double-stranded RNA binding
- enzyme binding
- protein homodimerization
- protein binding
- dsRNA-binding domain
- identical protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the Tarbp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- Burkitt lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- cardiomyopathy
- oligozoospermia
- systolic dysfunction
role in cell
- expression in
- proliferation
- differentiation
- processing in
- transformation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tarbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
- pre-miRNA processing
- production of miRNAs involved in gene silencing by miRNA
- negative regulation of protein kinase activity
- regulation of translation
- regulation of viral transcription
- negative regulation of defense response to virus by host
- positive regulation of viral genome replication
- small RNA loading onto RISC
- production of siRNA involved in RNA interference
- regulation of production of small RNA involved in gene silencing by RNA
- regulation of production of siRNA involved in chromatin silencing by small RNA
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- nuclear body
- cytoplasm
- cytosol
- RISC-loading complex
- RNA-induced silencing complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- pre-mRNA binding
- identical protein binding
- protein homodimerization activity
- protein binding
- double-stranded RNA binding
- siRNA binding
- pre-miRNA binding
- enzyme binding