BRD1 Gene Summary [Human]
This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | BRD1 |
| Official Name | bromodomain containing 1 [Source:HGNC Symbol;Acc:HGNC:1102] |
| Ensembl ID | ENSG00000100425 |
| Bio databases IDs | |
| Aliases | bromodomain containing 1, BR140-like |
| Synonyms | 1110059H06Rik, BRL, bromodomain containing 1, BRPF1, BRPF2, LOC380958, mKIAA4191 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BRD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- PHD zinc finger
- transcription regulator
- histone acetyltransferase
- Enhancer of polycomb-like
- protein binding activity, bridging
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
- Bromodomain
- PHD-finger
- PHD-like zinc-binding domain
- PHD finger superfamily
- PHD-zinc-finger like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- schizophrenia
- Alzheimer disease
- vascular dementia
- growth failure
regulated by
- histone H3
role in cell
- apoptosis
- expression in
- differentiation
- erythropoiesis
- missegregation
- number
- missegregation in
- dipeptide repeat protein sensitivity
- homologous recombination repair in
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nuclear speckles
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BRD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of developmental process
- chromatin remodeling
- regulation of transcription, DNA-dependent
- response to immobilization stress
- response to electrical stimulus
- positive regulation of erythrocyte differentiation
- regulation of transcription from RNA polymerase II promoter
- erythrocyte maturation
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- nuclear speck
- MOZ/MORF histone acetyltransferase complex
- perikaryon
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- histone binding
- histone acetyltransferase activity (H4-K8 specific)
- histone acetyltransferase activity (H4-K5 specific)
- histone acetyltransferase activity (H4-K12 specific)