Nubp1 Gene Summary [Mouse]
Predicted to enable iron-sulfur cluster binding activity. Acts upstream of or within centrosome localization; negative regulation of centrosome duplication; and protein localization to cell cortex. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human NUBP1 (NUBP iron-sulfur cluster assembly factor 1, cytosolic). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nubp1 |
| Official Name | nucleotide binding protein 1 [Source:MGI Symbol;Acc:MGI:1347073] |
| Ensembl ID | ENSMUSG00000022503 |
| Bio databases IDs | |
| Aliases | nucleotide binding protein 1 |
| Synonyms | CIAO5, NBP, NBP1, NBP35, NUBP iron-sulfur cluster assembly factor 1, NUBP iron-sulfur cluster assembly factor 1, cytosolic, NUBP iron-sulphur cluster assembly factor 1, NUBP iron-sulphur cluster assembly factor 1, cytosolic, nucleotide binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nubp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CobQ/CobB/MinD/ParA nucleotide binding domain
- nucleotide binding
- binding protein
- septum site-determining protein MinD
- NUBPL iron-transfer P-loop NTPase
- protein binding
- cell division ATPase MinD, archaeal
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
Pathways
Biological processes and signaling networks where the Nubp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- monoclonal gammopathy of undertermined significance
- mature B-cell neoplasia
- cutaneous B-cell lymphoma
- B-cell non-Hodgkin disease
- skin cancer
- cervical cancer
role in cell
- expression in
- growth
- formation
- maturation in
- amplification
- uptake in
- homeostasis in
- duplication
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- centrosome
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nubp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- centrosome localization
- protein localization to cell cortex
- regulation of cell growth
- negative regulation of centrosome duplication
- cell projection organization
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- centriole
- cilium
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- nucleotide binding
- ATP binding
- protein binding
- metal ion binding
- 4 iron, 4 sulfur cluster binding
- iron-sulfur cluster binding