Zyx Gene Summary [Mouse]
Predicted to enable metal ion binding activity. Involved in cell-matrix adhesion; integrin-mediated signaling pathway; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within cellular response to type II interferon. Located in focal adhesion and phagocytic vesicle. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and heart. Orthologous to human ZYX (zyxin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zyx |
| Official Name | zyxin [Source:MGI Symbol;Acc:MGI:103072] |
| Ensembl ID | ENSMUSG00000029860 |
| Bio databases IDs | |
| Aliases | zyxin |
| Synonyms | 9530098H06Rik, ESP-2, HED-2, ZIXIN, Zyxin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zyx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- alpha actinin binding domain
- protein binding
- Serine Proline motif
Pathways
Biological processes and signaling networks where the Zyx gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- liver cancer
- hepatocellular carcinoma
- epithelial cancer
- atopic dermatitis
- uterine leiomyoma
- leiomyomatosis
- gastric cancer
- severe acute respiratory syndrome
role in cell
- expression in
- migration
- phosphorylation in
- activation in
- formation
- proliferation
- growth
- formation in
- motility
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoskeleton
- Cytoplasm
- cell periphery
- focal adhesions
- actin cytoskeleton
- Nucleus
- microtubules
- costameres
- cytosol
- membrane ruffles
- nuclear bodies
- spindle pole
- myofibrils
- actin stress fibers
- filopodia
- cell membrane leading edge
- central spindle
- mitotic spindle
- phagosomes
- cell-cell adherens junctions
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zyx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- integrin-mediated signaling pathway
- transforming growth factor beta receptor signaling pathway
- cell-cell signaling
- cellular response to interferon-gamma
- stress fiber assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- adherens junction
- focal adhesion
- cytoplasm
- stress fiber
- actin cytoskeleton
- phagocytic vesicle
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding