Rhpn1 Gene Summary [Mouse]
Acts upstream of or within several processes, including focal adhesion assembly; glomerular filtration; and negative regulation of stress fiber assembly. Located in plasma membrane. Is expressed in several structures, including genitourinary system; hindlimb digit mesenchyme; musculoskeletal system; nervous system; and retina nuclear layer. Orthologous to human RHPN1 (rhophilin Rho GTPase binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rhpn1 |
| Official Name | rhophilin, Rho GTPase binding protein 1 [Source:MGI Symbol;Acc:MGI:1098783] |
| Ensembl ID | ENSMUSG00000022580 |
| Bio databases IDs | |
| Aliases | rhophilin, Rho GTPase binding protein 1 |
| Synonyms | BB023497, Grbp, mKIAA1929, ODF5, RHOPHILIN, rhophilin Rho GTPase binding protein 1, rhophilin, Rho GTPase binding protein 1, RHPN, RHPN1 rhophilin Rho GTPase binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rhpn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein-interacting Bro1-like domain of mammalian Alix and related domains
- Domain present in PSD-95, Dlg, and ZO-1/2
- BRO1-like domain
- canonical PDZ domain
- protein binding
- PDZ domain
- Rho-binding domain
- Hr1 repeat
- HR1
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Rhpn1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- breast carcinoma
- invasive breast carcinoma
- invasive breast cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- liver cancer
- hepatocellular carcinoma
role in cell
- activation in
- phosphorylation in
- formation
- assembly
- binding in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- Plasma Membrane
- cytosol
- outer dense fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rhpn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of stress fiber assembly
- signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding