Ndufb9 Gene Summary [Mouse]
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; integumental system; and nervous system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 24. Orthologous to human NDUFB9 (NADH:ubiquinone oxidoreductase subunit B9). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufb9 |
| Official Name | NADH:ubiquinone oxidoreductase subunit B9 [Source:MGI Symbol;Acc:MGI:1913468] |
| Ensembl ID | ENSMUSG00000022354 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase subunit B9 |
| Synonyms | 1190008J14Rik, B22, CI-B22, Complex I-B22, LYRM3, MC1DN24, NADH Dehydrogenase (Ubiquinone) 1 Beta B22 Subunit, NADH Dehydrogenase (Ubiquinone) 1 β B22 Subunit, Nadh-Q Oxidoreductase B22, Nadh Ubiquinone Oxidoreductase B22 Subunit, NADH:ubiquinone oxidoreductase subunit B9, NDUB9, UQOR22 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndufb9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complex 1 protein (LYR family)
- enzyme
- protein binding
- NADH2 dehydrogenase (ubiquinone)
- LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily
Pathways
Biological processes and signaling networks where the Ndufb9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- nuclear type 24 mitochondrial complex I deficiency
- malignant glioma
- glioma cancer
- adult acute myeloid leukemia
- androgenic alopecia
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- peripheral arterial disease
regulates
- reactive oxygen species
role in cell
- production in
- oxygen consumption rate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndufb9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- transmembrane transport
- mitochondrial electron transport, NADH to ubiquinone
- mitochondrial respiratory chain complex I assembly
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- NADH dehydrogenase (ubiquinone) activity