Ropn1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and protein heterodimerization activity. Acts upstream of or within several processes, including flagellated sperm motility; protein localization to cilium; and sperm capacitation. Located in sperm cytoplasmic droplet and sperm principal piece. Orthologous to several human genes including ROPN1 (rhophilin associated tail protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ropn1 |
| Official Name | ropporin, rhophilin associated protein 1 [Source:MGI Symbol;Acc:MGI:1923628] |
| Ensembl ID | ENSMUSG00000022832 |
| Bio databases IDs | |
| Aliases | ropporin, rhophilin associated protein 1 |
| Synonyms | 1700008N21Rik, CT91, ODF6, rhophilin associated tail protein 1, RHPNAP1, ROPN1A, ropporin, ropporin, rhophilin associated protein 1, Rppn |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ropn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dimerization domain
- protein binding
- DD_R_PKA_DPY30-like
- identical protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- organismal death
- melanoma
- melanoma cancer
- obstructive azoospermia
regulates
- cofilin
- RHOA
role in cell
- phosphorylation in
- activation in
- formation
- formation in
- motility
- migration
- invasion by
- capacitation
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- flagella
- cytosol
- sperm tail
- outer dense fibers
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ropn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm capacitation
- sperm motility
- regulation of protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- motile cilium
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding