Acr Gene Summary [Mouse]
Enables peptidase activity. Involved in single fertilization. Acts upstream of or within binding activity of sperm to zona pellucida and penetration of zona pellucida. Located in acrosomal vesicle. Is expressed in testis. Human ortholog(s) of this gene implicated in spermatogenic failure 87. Orthologous to human ACR (acrosin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acr |
| Official Name | acrosin prepropeptide [Source:MGI Symbol;Acc:MGI:87884] |
| Ensembl ID | ENSMUSG00000022622 |
| Bio databases IDs | |
| Aliases | acrosin prepropeptide |
| Synonyms | Acro, Acrosin, acrosin prepropeptide, SPGF87 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amidase
- Trypsin-like serine protease
- serine endopeptidase
- trypsin
- Tryp_SPc
- serine-type peptidase
- protease binding
- peptidase
- acrosin
- fucose binding
- protein binding
- mannose binding
Pathways
Biological processes and signaling networks where the Acr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- Golgi Apparatus
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- acrosome reaction
- penetration of zona pellucida
- response to steroid hormone stimulus
- acrosome matrix dispersal
- activation of adenylate cyclase activity
- single fertilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- macromolecular complex
- extracellular region
- acrosomal matrix
- Golgi-associated vesicle
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- mannose binding
- protein binding
- copper ion binding
- fucose binding
- amidase activity
- serine-type peptidase activity
- serine-type endopeptidase activity
- protease binding