Acrbp Gene Summary [Mouse]
Predicted to enable peptidase activator activity. Involved in acrosome assembly and fertilization. Located in acrosomal vesicle. Is expressed in testis. Orthologous to human ACRBP (acrosin binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acrbp |
| Official Name | proacrosin binding protein [Source:MGI Symbol;Acc:MGI:1859515] |
| Ensembl ID | ENSMUSG00000072770 |
| Bio databases IDs | |
| Aliases | proacrosin binding protein |
| Synonyms | acrosin binding protein, CT23, OY-TES-1, proacrosin binding protein, SP32 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acrbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Proacrosin binding protein sp32
- protein binding
- protease activator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck neoplasia
- organismal death
- globozoospermia
- asthenozoospermia
regulated by
- megakaryocytes
- diphtheria toxin
- desogestrel
- progesterone
regulates
role in cell
- proliferation
- formation
- formation in
- mitosis
- development
- abnormal morphology
- fragmentation
- motility
- fragmentation in
- autoactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acrbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acrosome assembly
- spermatid development
- fertilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- acrosomal membrane
- acrosomal vesicle
- extracellular region