Bfar Gene Summary [Mouse]
Predicted to enable caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and membrane. Is expressed in central nervous system; heart valve; reproductive system; and urinary system. Orthologous to human BFAR (bifunctional apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bfar |
| Official Name | bifunctional apoptosis regulator [Source:MGI Symbol;Acc:MGI:1914368] |
| Ensembl ID | ENSMUSG00000022684 |
| Bio databases IDs | |
| Aliases | bifunctional apoptosis regulator |
| Synonyms | 3010001A07Rik, 3110001I22Rik, AI666707, BAR, bifunctional apoptosis regulator, RGD1305537, RNF47 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bfar often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protease binding
- SAM (Sterile alpha motif )
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- SAM domain
- protein binding activity, bridging
- enzyme
- Ring finger domain
- protein binding
- Sterile alpha motif
- death effector domain-like
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- transmembrane domain
- SAM domain (Sterile alpha motif)
- DED recruiting domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- idiopathic scoliosis
role in cell
- apoptosis
- differentiation
- cell death
- expression in
- signaling in
- pravastatin sensitivity
- organismal death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bfar gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- negative regulation of apoptotic process
- protein polyubiquitination
- apoptotic process
- protein K63-linked ubiquitination
- ubiquitin-dependent protein catabolic process
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- protein binding, bridging