Rps3 Gene Summary [Mouse]
Enables DNA-(apurinic or apyrimidinic site) endonuclease activity. A structural constituent of ribosome. Involved in positive regulation of NF-kappaB transcription factor activity and positive regulation of protein-containing complex assembly. Located in cytoplasm. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in metanephros; pancreas epithelium; and telencephalon. Orthologous to human RPS3 (ribosomal protein S3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rps3 |
| Official Name | ribosomal protein S3 [Source:MGI Symbol;Acc:MGI:1350917] |
| Ensembl ID | ENSMUSG00000030744 |
| Bio databases IDs | |
| Aliases | ribosomal protein S3 |
| Synonyms | 40s ribosomal subunit, D7Ertd795e, ribosomal protein S3, Rs 3, S3, S3-40S, uS3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hsp70 protein binding
- heat shock protein binding
- transcription factor binding
- enzyme
- endonuclease
- structural constituent of ribosome
- KH domain
- tubulin binding
- Ribosomal protein S3, C-terminal domain
- protein kinase A binding
- protein kinase binding
- rRNA binding
- nucleic acid binding
- mRNA binding
- DNA-(apurinic or apyrimidinic site) lyase
- enzyme binding
- protein binding
- sequence-specific DNA binding
- ribosomal protein uS3, eukaryotic/archaeal type
- DNA binding
- RNA binding
- microtubule binding
- damaged DNA binding
- kinase binding
- binding protein
- K homology (KH) RNA-binding domain, type I
- double-stranded DNA binding
Pathways
Biological processes and signaling networks where the Rps3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- rheumatoid arthritis
- major depression
- preeclampsia
- lichen planus
- mucopolysaccharidosis type IVB
- alcoholism
role in cell
- cell death
- proliferation
- apoptosis
- phosphorylation in
- binding in
- assembly
- segregation
- response by
- function in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- multicilium
- cellular membrane
- ribosome
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- membrane ruffles
- mitochondrial matrix
- mitochondrial inner membrane
- nucleoplasm
- nucleoli
- synapse
- mitotic spindle
- dendrites
- postsynaptic density
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
- DNA repair
- positive regulation of JUN kinase activity
- base-excision repair
- cytoplasmic translation
- chromosome segregation
- positive regulation of NF-kappaB transcription factor activity
- cell division
- spindle assembly
- apoptotic process
- cellular response to tumor necrosis factor
- cellular response to hydrogen peroxide
- negative regulation of protein ubiquitination
- positive regulation of microtubule polymerization
- negative regulation of translation
- positive regulation of protein complex assembly
- positive regulation of interleukin-2 production
- positive regulation of DNA repair
- negative regulation of DNA repair
- regulation of apoptotic process
- response to DNA damage stimulus
- translational initiation
- positive regulation of activated T cell proliferation
- translation
- positive regulation of T cell receptor signaling pathway
- positive regulation of gene expression
- positive regulation of endodeoxyribonuclease activity
- cellular response to reactive oxygen species
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cytosolic ribosome
- cytosolic small ribosomal subunit
- endoplasmic reticulum
- nucleolus
- ribosome
- plasma membrane
- mitochondrial inner membrane
- nucleoplasm
- nucleus
- extracellular vesicular exosome
- focal adhesion
- mitotic spindle
- mitochondrial matrix
- cytoplasm
- membrane
- cytosol
- ruffle membrane
- NF-kappaB complex
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- endodeoxyribonuclease activity
- supercoiled DNA binding
- RNA binding
- mRNA binding
- DNA-(apurinic or apyrimidinic site) lyase activity
- DNA N-glycosylase activity
- kinase binding
- Hsp70 protein binding
- protein kinase binding
- SSU rRNA binding
- damaged DNA binding
- microtubule binding
- small protein conjugating enzyme binding
- DNA binding
- protein binding
- structural constituent of ribosome
- Hsp90 protein binding
- iron-sulfur cluster binding
- oxidized purine DNA binding
- oxidized pyrimidine DNA binding
- protein kinase A binding
- enzyme binding