Khdrbs3 Gene Summary [Mouse]
Predicted to enable RNA binding activity; identical protein binding activity; and protein domain specific binding activity. Involved in regulation of mRNA splicing, via spliceosome. Located in nucleoplasm. Is expressed in several structures, including central nervous system; genitourinary system; lung; sensory organ; and stomach. Orthologous to human KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Khdrbs3 |
| Official Name | KH domain containing, RNA binding, signal transduction associated 3 [Source:MGI Symbol;Acc:MGI:1313312] |
| Ensembl ID | ENSMUSG00000022332 |
| Bio databases IDs | |
| Aliases | KH domain containing, RNA binding, signal transduction associated 3 |
| Synonyms | ETLE, etoile, KH domain containing, RNA binding, signal transduction associated 3, KH RNA binding domain containing, signal transduction associated 3, SALP, SLM-2, T-STAR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Khdrbs3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Arg-Gly dipeptide repeat domain
- Qua1 domain
- K homology (KH) RNA-binding domain, type I
- protein domain specific binding
- protein binding
- Tyrosine-rich domain of Sam68
- single-stranded RNA binding
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- neoplasia
- hepatocellular carcinoma
- organismal death
- Alzheimer disease
- medulloblastoma
- brain cancer
- glioblastoma
- glioblastoma cancer
regulates
- KHDRBS3
- reporter gene
- REV
role in cell
- proliferation
- apoptosis
- doxorubicin sensitivity
- alternative splicing by
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Khdrbs3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of alternative nuclear mRNA splicing, via spliceosome
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein domain specific binding
- RNA binding
- protein binding
- mRNA binding
- SH3 domain binding