B3gnt5 Gene Summary [Mouse]
Predicted to enable N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity and lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity. Predicted to be involved in central nervous system development and protein O-linked glycosylation. Predicted to act upstream of or within sphingolipid biosynthetic process. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human B3GNT5 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | B3gnt5 |
| Official Name | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 [Source:MGI Symbol;Acc:MGI:2137302] |
| Ensembl ID | ENSMUSG00000022686 |
| Bio databases IDs | |
| Aliases | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 |
| Synonyms | beta3Gn-T5, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5, UDP-GlcNAc:betaGal β-1,3-N-acetylglucosaminyltransferase 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse B3gnt5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
- UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase
- galactosyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rotator cuff injury
- obesity
- androgenic alopecia
- chronic obstructive pulmonary disease
regulates
- glycolipid
- CD19
- IgG
- IgG2a
- glycosphingolipid
- O-glycan
- sphingolipid
- lactotriaosylceramide
- ganglioside GM1
- IgG2b
role in cell
- number
- proliferation
- tyrosine phosphorylation in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse B3gnt5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- protein O-linked glycosylation
- protein glycosylation
- glycolipid biosynthetic process
- O-glycan processing
- glycosphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
- UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity