Cd19 Gene Summary [Mouse]
Involved in several processes, including B-1 B cell differentiation; positive regulation of release of sequestered calcium ion into cytosol; and regulation of signal transduction. Acts upstream of or within B cell receptor signaling pathway. Located in external side of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in common variable immunodeficiency 3. Orthologous to human CD19 (CD19 molecule). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cd19 |
| Official Name | CD19 antigen [Source:MGI Symbol;Acc:MGI:88319] |
| Ensembl ID | ENSMUSG00000030724 |
| Bio databases IDs | |
| Aliases | CD19 antigen |
| Synonyms | B4, CD19 ANTIGEN, CD19 molecule, CVID3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- ectodomain
- signal peptide
- central domain
- CD19_double_Ig
- cytoplasmic domain
- transmembrane domain
- Immunoglobulin like
- immunoglobulin-like protein domain
- intracellular domain
- cytosolic tail domain
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Cd19 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- precursor B-cell acute lymphoblastic leukemia
- extranodal marginal zone cell lymphoma
- systemic sclerosis
- diffuse large B-cell lymphoma transformed from indolent lymphoma
- high-grade B-cell lymphoma
- transformed diffuse large B-cell lymphoma
- primary mediastinal large B-cell lymphoma
- refractory diffuse large B-cell lymphoma
role in cell
- production in
- apoptosis
- expression in
- mobilization in
- quantity
- survival
- loss
- proliferation
- adhesion
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- antigen receptor-mediated signaling pathway
- B-1 B cell differentiation
- immunoglobulin mediated immune response
- positive regulation of release of sequestered calcium ion into cytosol
- regulation of B cell receptor signaling pathway
- positive regulation of protein kinase B signaling cascade
- B cell proliferation involved in immune response
- regulation of B cell activation
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane raft
- external side of plasma membrane
- macromolecular complex
- plasma membrane