Tnpo3 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and small GTPase binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in annulate lamellae and nuclear envelope. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 2. Orthologous to human TNPO3 (transportin 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnpo3 |
| Official Name | transportin 3 [Source:MGI Symbol;Acc:MGI:1196412] |
| Ensembl ID | ENSMUSG00000012535 |
| Bio databases IDs | |
| Aliases | transportin 3 |
| Synonyms | 5730544L10Rik, C430013M08RIK, D6Ertd313e, IPO12, LGMD1F, LGMDD2, mKIAA4133, MTR10A, NUCLEAR TRANSPORT receptor, transportin 3, Transportin-SR, TRN-SR, TRN-SR2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnpo3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Exportin 1-like protein
- alpha helix
- enzyme binding
- protein binding
- Importin-beta N-terminal domain
- identical protein binding
- cargo binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- hypothyroidism
- limb-girdle muscular dystrophy type 1F
- leiomyomatosis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- systemic sclerosis
- systemic lupus erythematosus
- primary biliary cirrhosis
- myositis
role in cell
- expression in
- migration
- proliferation
- quantity
- integration in
- differentiation
- nuclear import in
- replication in
- dissemination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- endomembrane system
- Nucleus
- cytosol
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnpo3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into nucleus
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- cytoplasm
- intracellular membrane-bounded organelle
- annulate lamellae
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- small GTPase binding